Magnetic nanoparticles for cancer therapy and other biomedical applications

  • Hariharan Srikanth University of South Florida
Keywords: Nanomaterials, Magnetism, Biophysics


Magnetic nanoparticles are being developed for applications ranging from high density recording, spintronic devices to nanomedicine. Magnetic hyperthermia is one of the most promising new techniques for cancer treatment. Although spherical iron oxide nanoparticles are commonly studied for a variety of biomedical applications, their relatively small saturation magnetization and small effective anisotropy result in a relatively low heating efficiency or Specific Absorption Rate (SAR). In order to boost the heating efficiency of iron oxide nanoparticles, different options have been considered, such as increasing their saturation magnetization, changing their size, shape, anisotropy etc. In this talk I will discuss the application of functional magnetic nanoparticles in nanomedicine including magnetic hyperthermia treatment of cancer, contrast enhancement in MRI and biosensors based on giant magnetoimpedance (GMI). There is a need to improve the specific absorption rate (SAR) and heating efficiency of nanoparticles for hyperthermia and our recent work has focused on the role of surface and interfacial anisotropy with a goal to enhance SAR. Strategies that go beyond simple spherical structures such as core-shell nanoparticle, exchange-coupled nanoparticles, nanowire, nanotube geometries can be exploited to increase saturation magnetization, effective anisotropy and heating efficiency in magnetic hyperthermia treatment of cancer cells.

About the Speaker

Hariharan Srikanth is a Professor of Physics at the University of South Florida. He received his Ph.D. in experimental condensed matter physics from the Indian Institute of Science in 1994. After postdoctoral research for several years, Hari joined the University of South Florida in 2000 as an Assistant Professor and established the Functional Materials Laboratory. He became a Full Professor in 2009. His current research topics include investigating magnetization dynamics in nanostructures, exchange bias, magnetic refrigerant materials, giant magneto-impedance (GMI), microwave materials, complex oxides with competing magnetic phases, spin caloric effects and applications of magnetic nanoparticles in nanomedicine. He has over 235 journal publications and holds two patents and has given over 130 invited talks and tutorials around the world. Hari is a Fellow of the American Physical Society, Fellow of Institute of Nanotechnology, Marie Curie Fellow, International Association of Advanced Materials (IAAM) Medal recipient in 2016, and a senior member of IEEE. He is currently an Associate Editor for the Journal of Applied Physics. Hari has been associated with the Magnetism and Magnetic Materials (MMM) conferences for several years as a program and steering committee member, publication editor and publication chair. He is one of the publication chairs for the 2018 International Conference on Magnetism (ICM) to be held in San Francisco. His research program over the years has received funding from the US Department of Energy, Army Research Office, National Science Foundation, Bizkaia Talent Program (Basque Country, Spain). Hari has held several short term visiting professor positions in Europe at Slovak Academy of Sciences (Kosice), Basque Center for Materials (Bilbao) and in Asia at the Indian Institute of Science (Bangalore) and Indian Institute of Technology (Bombay).